Tess Lawrie (director of the Evidence-based Medicine Consultancy in Bath, UK) has recently released a meta-analysis of ivermectin data regarding its use as COVID-19 treatment and prophylaxis. Please see https://www.researchgate.net/publication/348297284_Ivermectin_reduces_the_risk_of_death_from_COVID-19_-a_rapid_review_and_meta-analysis_in_support_of_the_recommendation_of_the_Front_Line_COVID-19_Critical_Care_Alliance_Latest_version_v12_-_6_Jan_2021
She started with 27 randomized (RCT) and observational controlled trials (OCT) mentioned by the FLCCC (https://covid19criticalcare.com/) and pared them down to 9 RCT and 6 OCT. This resulted in 1835 subjects in the treatment analysis and 1542 in the prophylaxis analysis. She considered a number of endpoints. But if I include just those not subject to investigator bias, she finds that the risk of dying is reduced by 62 to 92%. With respect to prophylaxis, the chances of developing a positive PCR test is reduced by ~88%.
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